For the ancient Italic peoples it was a sacred river. On the shores, they erected sanctuaries such as the Demetra and Teano one.

It is one of the favourite stopping points in the long spring migration from Africa to Central Eastern Europe on the Tyrrhenian route.

Mount Massico with its 813 meters is the highest relief of the mountain range which starts from the slopes of the Roccamonfina volcano and reaches the Tyrrhenian Sea.